http://nopr.niscair.res.in/handle/123456789/6425 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/6774 Title: Correlation between the <i style="">p</i>Ka and pharmacological properties of some imidazolin-5(4<i style="">H</i>)-ones, their precursors and Schiff’s bases <br/> <br/>Authors: Gupta, J K; De, Biplab; Saravanan, V S <br/> <br/>Abstract: The <i style="">p</i>Ka value of some synthesized imidazolin-5(4<i style="">H</i>)-ones and their precursors, Schiff’s bases are determined by potentiometric method and the analgesic activity and CNS depressant property are evaluated, which are correlated with the <i style="">p</i>Ka values. It is found that a correlation established in best fit curve of 3^rd order polynomial equation. <br/> <br/>Page(s): 2580-2582 http://nopr.niscair.res.in/handle/123456789/6773 Title: Isolation of chalkones from the seeds of <i style="">Psoralea corylifolia</i> Linn. <br/> <br/>Authors: Agarwal, Deepshikha; Garg, S P; Sah, Pramilla <br/> <br/>Abstract: Isolation and characterization of a new chalkone namely 4,2<i>'</i>-dihydroxy-2<i>''</i>-(1<i>'''</i>-methyl ethyl)-2<i>''</i>-3<i>''</i>-dihydro-(4<i>''</i>,5<i>''</i>,3<i>'</i>,4<i>'</i>) furano chalkone <b style="">1</b> along with a known chalkone 4,2<i>'</i>-dihydroxy-4<i>'</i>-methoxy-5'-(3<i>'''</i>, 3<i>'''</i>-dimethyl allyl)-chalkone <b style="">2</b> have been carried out from the seeds of the desert variety of <i style="">Psoralea corylifolia</i> Linn on the basis of spectral data analysis <i style="">i.e.</i> IR, ¹H NMR, mass and chemical reactions. <br/> <br/>Page(s): 2574-2579 http://nopr.niscair.res.in/handle/123456789/6772 Title: Microwave induced, solvent-free Knoevenagel condensation of 4-oxo-(<i style="">4H)</i>-1-benzopyran-3-carbaldehyde with Meldrum’s acid using alumina support <br/> <br/>Authors: Shindalkar, S S; Madje, B R; Shingare, M S <br/> <br/>Abstract: A rapid, solvent-free and environmentally friendly Knoevenagel condensation reaction of 4-oxo-(4<i style="">H</i>)-1-benzopyran-3-carbaldehyde <b style="">1</b> with Meldrum’s acid <b style="">2</b> has been carried out under microwave irradiation. The structures of condensed products <b style="">3a-g</b> have been characterized on the basis of IR and ¹H NMR spectral data. <br/> <br/>Page(s): 2571-2573 http://nopr.niscair.res.in/handle/123456789/6771 Title: Exploring QSAR of peripheral benzodiazepine receptor binding affinity of 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl-acetamides using topological and physicochemical descriptors <br/> <br/>Authors: Dalai, Manoj Kumar; Leonard, J Thomas; Roy, Kunal <br/> <br/>Abstract: The structural and physicochemical requirements of 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl-acetamides for binding with peripheral benzodiazepine receptor has been explored in the present QSAR study. The calculated hydrophobicity, <i style="">logP_calc</i>, shows a parabolic relation with the peripheral benzodiazepine receptor binding affinity, which suggests that the binding affinity increases with increase in the partition coefficient of the compounds until it reaches the critical value after which the affinity decreases. The range of the optimum values of <i style="">logP_calc</i> is between 5.423-5.819 as found from different equations. The width of the <i style="">para</i> substituents at R₃ position is conducive for the binding affinity. The E-state values of the fragments like methyl,<img src='/image/spc_char/ijcb_nov06_2.gif' border=0> ,<img src='/image/spc_char/ijcb_nov06_1.gif' border=0> and <img src='/image/spc_char/ijcb_nov06_3.gif' border=0> are conducive for the binding affinity, while E-state value of the fragment -F is detrimental to the binding affinity. The average distance sum of the connectivity (Balaban <i style="">J</i>) among different groups is also conducive for the binding affinity. The presence of methyl groups at R₁ and R₂ positions and the presence of substituents at R₅ position are detrimental to the binding affinity, while presence of substituents at R₃ position and the presence of methyl group at R₆ position are conducive to the binding affinity. <br/> <br/>Page(s): 2497-2505