http://nopr.niscair.res.in/handle/123456789/5173 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/5518 Title: <i style="">In vivo </i>interactive effect of garlic oil and vitamin E against stavudine induced genotoxicity in <i style="">Mus musculus </i> <br/> <br/>Authors: Kaur, Pushpindar; Singh, Rattan <br/> <br/>Abstract: Stavudine (Zerit, d4T) is widely used as an anti HIV infection drug. It prevents HIV by altering the genetic material of healthy cells but causes mutations in mitochondrial and nuclear DNA. It also produces clastogenic effects in mice. In the present investigation, comet assay test was applied to evaluate the possible genomic damage caused by stavudine and also the ameliorating effects of garlic oil and vitamin E against its genotoxicity in different organs of mice. Two different doses of garlic oil (low and high dose) and vitamin E were administered to mice separately and in combination for six consecutive days followed by a dose of stavudine. The mice were sacrificed after 24, 48 and 72 h of stavudine administration. Both the antioxidants (vitamin E and garlic oil) separately and in combination reduced the genotoxicity of stavudine. The protective effects of high doses of garlic oil were more pronounced as compared to vitamin E administered group. <br/> <br/>Page(s): 807-811 http://nopr.niscair.res.in/handle/123456789/5515 Title: Hypoglycemic and hypolipidemic effects of alcoholic extract of <i style="">Tribulus alatus </i>in streptozotocin-induced diabetic rats: A comparative study with<i style=""> T. terrestris </i>(Caltrop)<i style=""></i> <br/> <br/>Authors: El-Tantawy, W H; Hassanin, L A <br/> <br/>Abstract: The extracts of both <i style="">T. alatus </i>and <i style="">T. terrestris</i> significantly decrease fasting glucose level in diabetic rats. After 4 and 6 hr, <i style="">T. alatus</i> extract showed significant reduction in glucose level as compared to <i style="">T. terrestris. </i>After 3 weeks of treatment with <i style="">T. alatus</i> extract, glucose level was significantly decreased to the normal level. Both the extracts also caused a significant decrease in the levels of glycosylated hemoglobin, total cholesterol, triglycerides and LDL-cholesterol. The percent of reduction in rats treated with <i style="">T. alatus</i> extract was significantly higher than that of the rats treated with <i style="">T. terrestris. </i>The results indicate that alcoholic extract of <i style="">T. alatus</i> possesses hypoglycemic activity in type-1 model of diabetes. <br/> <br/>Page(s): 785-790 http://nopr.niscair.res.in/handle/123456789/5514 Title: Factors affecting induction and development of <i style="">in vitro</i> rooting in apple rootstocks <br/> <br/>Authors: Sharma, T; Modgil, M; Thakur, M <br/> <br/>Abstract: Shoots of apple rootstocks raised <i style="">in vitro</i> were transferred to various rooting media to study the effect of different factors on root initiation and development. Various concentrations of indole-3-butyric acid (IBA) initiated rooting but maximum rooting percentage was found with 2.0 and 2.5 mg l^-1 of IBA in M7 and with 1.0 mg l^-1 of IBA in MM106. The drawback was that the roots were thick, short and with profuse callus. The presence of activated charcoal (AC) in the rooting medium improved the rooting quality but reduced the rooting percentage in both the rootstocks. In high auxin dip of 70, 80 and 90 mg l^-1 IBA for 2, 2 and 1 hr showed 75-85 per cent rooting in M7, but lacked reproducibility of the results. Whereas in MM106, 66 – 70 % rooting was achieved with 70 mg l^-1 of IBA dip for 3 h. Root induction in shoots in IBA containing liquid medium (LM) in dark for few days and root elongation in IBA - free medium in light proved most effective. On the other hand, continuous light treatment showed reduced rooting. Reduction of MS salts and sucrose in root elongation medium showed decreased rooting. Plantlets from two - stage rooting procedure showed more rapid growth and satisfactory survival during hardening of plants and on transfer to field. <br/> <br/>Page(s): 824-829 http://nopr.niscair.res.in/handle/123456789/5328 Title: Effects of monosodium glutamate on food acceptance and toxicity of selenium in rats <br/> <br/>Authors: Parshad, R K; Natt, J K <br/> <br/>Abstract: Food acceptance and toxic effects of feeding sodium selenite (Se) alone and in combination with monosodium glutamate (MSG), a taste enhancer were studied in the laboratory rat. Dose-dependent stimulation of daily food intake was observed with MSG offered in no-choice or bi-choice with the plain food. Consumption of pellets containing 0.05, 0.5 and 1.0% Se was significantly low than the plain or MSG containing pellets but their active ingredient was sufficient to cause mortality of rats. Food pellets containing both MSG and Se in no-choice feeding trial were not preferred by the rats, as their consumption remained low as compared to pellets containing only MSG. However, prior feeding on MSG containing pellets for two days increased the amount of intake of Se-containing pellets. No mortality of rats feeding on pellets containing different concentrations of MSG was recorded. Feeding on Se-containing pellets caused dose-dependent mortality on the third day of the trial. As compared to rats feeding on Se-containing pellets, the mortality rate was reduced in those provided Se in combination with MSG but the intake of active ingredient of Se in both these trials did not differ significantly. Decrease in death rate of rats feeding on Se in combination with MSG containing pellets suggested that addition of MSG to seleniferous food probably provide protection to some extent from the toxic effects of selenium. However, combination of excess doses of MSG and Se in food pellets caused mortality of all experimental animals. <br/> <br/>Page(s): 802-806