http://nopr.niscair.res.in/handle/123456789/4403 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/4571 Title: Hypoglycemic potential of <i style="">Morus indica. </i>L and <i style="">Costus igneus. </i>Nak<i style="">.</i>—A preliminary study <br/> <br/>Authors: D, Vishalakshi Devi.; Urooj, Asna <br/> <br/>Abstract: Powdered leaves (500 mg/kg body weight) of medicinal plants <i style="">M. indica </i>and <i style="">C. igneus</i> known to possess therapeutic effect were supplemented to streptozotocin induced diabetic rats. Leaf powders of both the plants were able to reduce blood glucose levels in the animals by 38 and 21% respectively after 15 days of supplementation. The preliminary results suggest that both the plants possess potent hypoglycemic activity. <br/> <br/>Page(s): 614-616 http://nopr.niscair.res.in/handle/123456789/4570 Title: Antihyperglycaemic activity of aqueous extract of <i style="">Embelia ribes</i> Burm in streptozotocin-induced diabetic rats <br/> <br/>Authors: Bhandari, Uma; Ansari, M Nazam <br/> <br/>Abstract: Forty days of orally feeding the aqueous <i style="">E. ribes</i> extract (100 and 200 mg/kg) to streptozotocin (40 mg/kg, iv, single dose) induced diabetic rats produced significant decrease in heart rate, systolic blood pressure, blood glucose, blood glycosylated hemoglobin, serum lactate dehydrogenase, creatine kinase and increase in blood glutathione levels as compared to pathogenic diabetic rats. Further, the extract significantly decreased the levels of pancreatic lipid peroxides and increased the levels of pancreatic superoxide dismutase, catalase and glutathione. The results suggest that aqueous <i style="">E. ribes </i>extract exhibits a significant blood glucose and blood pressure lowering potential. Further, it enhances endogenous antioxidant defense against free radicals produced under hyperglycaemic conditions, thereby, seemingly protects the pancreatic b-cells against loss in streptozotocin induced diabetic rats. <br/> <br/>Page(s): 607-613 http://nopr.niscair.res.in/handle/123456789/4569 Title: Antidiabetic activity of a polyherbal formulation (DRF/AY/5001) <br/> <br/>Authors: Mandlik, Rahul V; Desai, Sandya K; Naik, Suresh R; Sharma, Gaurav; Kohli, R K <br/> <br/>Abstract: The herbal formulation, DRF/AY/5001, elicits hypoglycemic/antidiabetic effects in both normal and experimentally induced hyperglycemic (epinephrine and alloxan) rats. Further, herbal formulation treatment can significantly alter the pattern of glucose tolerance in normal and diabetic rats. It is possible that the herbal formulation may act through both, pancreatic and extra-pancreatic mechanism(s). The DRF/AY/5001 also elicited a significant antioxidant effect in alloxan diabetic rats as reflected by its ability to inhibit lipid peroxidation and to elevate the enzymatic antioxidants in pancreatic tissue. The histopathological studies during the long term treatment have shown to ameliorate the alloxan induced histological damage of islets of Langerhans. The inhibitory effects on biochemical and histological parameters induced by herbal formulation at a dose of 600 mg/kg were almost comparable to that of standard drug, glibenclamide (4 mg/kg). The present study demonstrates that herbal formulation exhibits promisisng antidiabetic activity and helps to maintain good glycemic and metabolic control. <br/> <br/>Page(s): 599-606 http://nopr.niscair.res.in/handle/123456789/4568 Title: Nootropic activity of tuber extract of <i>Pueraria tuberosa</i> (roxb) <br/> <br/>Authors: Rao, N Venkata; Pujar, Basavaraj; Nimbal, S K; Shantakumar, S M; Satyanarayana, S <br/> <br/>Abstract: Nootropic effect of alcoholic (ALE; 50, 75, 100 mg/kg) and aqueous (AQE; 100, 200, 400 mg/kg) extracts of <i>P</i>. <i>tuberosa</i> was evaluated by using Elevated Plus Maze (EPM), scopolamine-induced amnesia (SIA), diazepam-induced amnesia (DIA), clonidine-induced (NA-mediated) hypothermia (CIH), lithium-induced (5-HT mediated) head twitches (LIH) and haloperidol-induced (DA- mediated) catalepsy (HIC) models. Piracetam was used as the standard drug. A significant increase in inflexion ratio (IR) was recorded in EPM, SIA and DIA models. A significant reversal effect was observed on rectal temperature in CIH model, reduction of head twitches in LIH models. However no significant reduction in catalepsy scores in HIC models were observed with test extracts and standard piracetam. The results indicate that nootropic activity observed with ALE and AQE of tuber extracts of <i>P. tuberosa </i>could be through improved learning and memory either by augmenting the noradrenaline (NA) transmission or by interfering with 5-hydroxytryptamine (5-HT) release. Further, the extracts neither facilitated nor blocked release of the dopamine (DA). Thus ALE and AQE elicited significant nootropic effect in mice and rats by interacting with cholinergic, GABAnergic, adrenergic and serotonergic systems. Phytoconstituents like flavonoids have been reported for their nootropic effect and these are present in both ALE and AQE extracts of tubers of <i>P. tuberosa</i> (Roxb) and these active principles may be responsible for nootropic activity. <br/> <br/>Page(s): 591-598