http://nopr.niscair.res.in/handle/123456789/4402 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/4546 Title: Effect of DENA induced hepatocarcinogenesis on neuroendocrine levels in male rats <br/> <br/>Authors: Ghosh, A S; Bhattacharyya, D; Chandra, M; Bhattacharyya, T K <br/> <br/>Abstract: Hepatocarcinogenesis was induced in Sprague Dawley rats by injecting diethylnitrosamine (DENA); 150 mg/kg body weight, ip, a well known liver carcinogen and a mutagenic agent. Concurrent with the induction of hepatocarcinoma, psychological stress was also elicited from the changes in brain neurotransmitters. Noradrenaline and dopamine, the neurotransmitters of sympathetic system were estimated from the whole brain and corresponding hormones T₃, T₄ and prolactin were estimated from the blood of such rats. The neuroendocrine cascade and the marker enzyme gamma glutamyl transferase were estimated at 7, 14, 21 and 30 weeks. A direct relationship between noradrenaline, T₃ and T₄ and a reciprocal relationship between dopamine and prolactin were observed, which may be correlated to the carcinogenic effect of DENA. <br/> <br/>Page(s): 498-504 http://nopr.niscair.res.in/handle/123456789/4545 Title: <b style="">Book Review</b> <br/> <br/>Abstract: Genomics and Genetic Engineering <br>P Ananda Kumar & Sharmistha Barthakur <br/> <br/>Page(s): 550 http://nopr.niscair.res.in/handle/123456789/4544 Title: Effect of <i>Bacopa monniera</i> (Linn.) on lipid peroxidation and lipofuscinogenesis in prostate gland of D-galactose induced aging mice, <i>Mus musculus</i> <br/> <br/>Authors: Kalamade, V I; Pillai, M M; Kalamade, I S <br/> <br/>Abstract: The levels of malondialdehyde and lipofuscin pigments were increased in the prostate of D-galactose (0.5 ml/day, sc, for 20 days) induced aging mice. After <i style="">B. monniera</i> (40 mg/kg body weight for 20 days) ethanol leaf extract administration levels of both the parameters were reduced significantly. The results suggest that <i style="">B. monniera </i>prevents formation of malondialdehyde and lipofuscin pigments which are the indicators of aging. <br/> <br/>Page(s): 547-549 http://nopr.niscair.res.in/handle/123456789/4543 Title: Lowering of intraocular pressure by topical application of <i>Daucus carota </i>seed extract in rabbits <br/> <br/>Authors: Agarwal, Renu; Gupta, S K; Srivastava, Sushma; Agrawal, S S; Saxena, Rohit <br/> <br/>Abstract: In normotensive rabbits topical application of <i>Daucus carota </i>seed extract at the concentration of 0.3, 0.6 and 1.2% resulted in mean IOP reduction of 19.33. 23.20 and 25.61% respectively from baseline. As no significant difference was observed between the change in IOP in 0.6 and 1.2% extract treated groups, 0.6% concentration was chosen for further evaluation in rabbits with experimentally elevated IOP. In water loaded rabbits, maximum mean IOP reduction with 0.6% extract was 29.39%, which was comparable to pilocarpine. In steroid pretreated rabbits, maximum mean IOP reduction was 30.27% from baseline, which was significantly higher than pilocarpine. The extract showed a comparatively slower onset of action however, the duration of action was comparable to pilocarpine in all the experimental models. <br/> <br/>Page(s): 541-546