http://nopr.niscair.res.in/handle/123456789/4398 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/4453 Title: Effect of propofol in altering pentylenetetrazol induced seizure threshold in rats <br/> <br/>Authors: Prakash, A; Medhi, B; Puri, A; Saikia, B <br/> <br/>Abstract: The present study was undertaken to evaluate the role of propofol in altering pentylenetetrazol induced seizure threshold in rats. Total 42 Wistar rats were used to evaluate different parameters (onset of action, duration of seizure, seizure severity score and number of seizure) following propofol injection. The present results showed that there was significant reduction in the time required for onset of seizure in propofol treated groups following PTZ treatment. If treated with propofol alone (2 and 5mg/kg), there was no significant difference as compared to controls. In seizure severity score assessment, there was no significant difference with various doses of propofol alone treated groups, but the difference was observed in propofol (2 and 5 mg/kg) treated groups following PTZ treatment. Duration of seizure also significantly increased in propofol (5mg/kg) treated group, but at 2mg/kg of propofol treatment, no significant difference was observed. The present results showed that propofol ameliorate seizure threshold and caused prolongation of duration of seizure. However, further study and trials are needed to confirm the present results. <br/> <br/>Page(s): 196-200 http://nopr.niscair.res.in/handle/123456789/4452 Title: Surface morphology of immunocompetent cells isolated from spleen of <i style="">Bufo himalayanus </i>(Gunther) <br/> <br/>Authors: Bhattacharjee, Koutilya; Das, Sanjib Kr <br/> <br/>Abstract: Immunocompetent cells were isolated from spleen of <i style="">B. himalayanus</i> and studied surface morphology of the three different cell types - (i) plastic adherent; (ii) nylon wool adherent; and (iii) nylon wool non-adherent cells. As revealed by scanning electron microscopy, they resembled the macrophages, B and T cells, respectively. Presence of such cell types indicated that <i style="">Bufo himalayanus</i> possessed a well-organized immune system. Further work is needed to characterize the functional efficacy of these immunocompetent cells found in <i style="">B. himalayanus</i>. <br/> <br/>Page(s): 191-195 http://nopr.niscair.res.in/handle/123456789/4451 Title: CNS depressive role of aqueous extract of <i>Spinacia oleracea</i> L. leaves in adult male albino rats <br/> <br/>Authors: Das, Sutapa; Guha, Debjani <br/> <br/>Abstract: Treatment with <i style="">Spinacia oleracea</i> extract (SO; 400 mg/kg body weight) decreased the locomotor activity, grip strength, increased pentobarbitone induced sleeping time and also markedly altered pentylenetetrazole induced seizure status in Holtzman strain adult male albino rats. SO increased serotonin level and decreased both norepinephrine and dopamine levels in cerebral cortex, cerebellum, caudate nucleus, midbrain and pons and medulla. Result suggests that SO exerts its CNS depressive effect in PTZ induced seizure by modulating the monoamines in different brain areas. <br/> <br/>Page(s): 185-190 http://nopr.niscair.res.in/handle/123456789/4450 Title: Antidepressant activity of fosinopril, ramipril and losartan, but not of lisinopril in depressive paradigms of albino rats and mice <br/> <br/>Authors: Nayak, Veena; Patil, P A <br/> <br/>Abstract: Fosinopril, ramipril and losartan significantly decreased the duration (sec) of immobility in forced swim test and were comparable to amitriptyline. The duration of immobility were significantly decreased in fosinopril, ramipril and losartan in the tail suspension test and were comparable to amitriptyline. Only losartan significantly increased the rearing number of entries, time spent (sec) in open arm and in light area in comparison to control animals. Fosinopril and ramipril and not lisinopril showed significant antidepressant activity while losartan showed a significant antidepressant and anxiolytic activity. Present findings suggest that these drugs could be better antihypertensives in hypertensive patients with co-morbidity like depression or anxiety. <br/> <br/>Page(s): 180-184