http://nopr.niscair.res.in/handle/123456789/315 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/3852 Title: Naphthalene azomesogens with terminal chloro groups <br/> <br/>Authors: Thaker, B T; Patel, D M; Tandel, P K <br/> <br/>Abstract: A homologous series of azomesogens, with terminal chloro groups have been synthesized. All the homologous synthesized compounds exhibit enantiotropic nematic mesophase. The mesomorphic properties of the present series are compared with other structurally related series to evaluate the effect of terminal chloro group and its position on mesomorphism. <br/> <br/>Page(s): 1020-1024 http://nopr.niscair.res.in/handle/123456789/651 Title: Solventless synthesis of 2,4,10a-triaryl-1,10a-dihydro- 2H-pyrazino[2,1-b][1,3] benzoxazole <br/> <br/>Authors: Ravindran, G; Muthusubramanian, S; Selvaraj, S; Perumal, S <br/> <br/>Abstract: A solventless synthesis of 2,4,10a-triaryl-1,10a-dihydro-2H-pyrazino[2,1-b][1,3] benzoxazole has been achieved in good yield by the reaction of 2-[(2-oxo-2-arylethyl) anilino]-1-aryl-1-ethanones with 2-aminophenol in p-toluenesulfonic acid. The products have been characterized by ¹H and ¹³C NMR spectroscopy. <br/> <br/>Page(s): 1047-1050 http://nopr.niscair.res.in/handle/123456789/650 Title: 3D-QSAR analysis of cycloguanil derivatives, highly active agents against A16V + S108T mutant of dihydrofolate reductase resistant strain (T9/94) of Plasmodium falciparum <br/> <br/>Authors: Singh, Vineet; Tiwari, Meena <br/> <br/>Abstract: 3D-Quantitative-structure activity relationship of some 4,6-diamino-1,2-dihydrotriazine derivatives (cycloguanils) having good activity against resistant strain of P. falciparum has been performed. The model developed has shown that the descriptors, ovality (steric descriptor), dipole-dipole energy (thermodynamic descriptor) contributing positively while stretch bend energy (thermodynamic descriptor) negatively to the biological activity. Statistical analysis has shown the model to be fit (R=0.924, R²=0.853, F-test=18.840, t-test=4.340, stdev = 0.244, variance=0.051) and predictable (R²ւօօ=0.693, R²pred=0.265). It can be concluded that parent nuclei having functional groups with optimum values for these descriptors, might have better biological activity against resistant strains. <br/> <br/>Page(s): 1042-1046 http://nopr.niscair.res.in/handle/123456789/649 Title: Unusual KMnO₄oxidation product of β-ionone <br/> <br/>Authors: Kamat, Shrivallabh P; D’Souza, Asha M; Paknikar, Shashikumar K; Bhadbhade, Mohan M; Gonnade, Rajesh G <br/> <br/>Abstract: KMnO₄ oxidation of β-ionone has been reinvestigated. The structure proposed for the hydroxyionolactone 3 obtained in this reaction is supported by MS, UV, IR, ¹H and ¹³C NMR data and further confirmed by single crystal X-ray diffraction studies of the bromolactone 8. <br/> <br/>Page(s): 1038-1041