http://nopr.niscair.res.in/handle/123456789/309 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/3853 Title: Model study on the sequence specific stacking by chromophore of an anticancer drug, acridine carboxamide with base pairs of DNA <br/> <br/>Authors: Parajuli, Raghab; Sarma, Rajib Lochan; Das, Manas Lochan; Medhi, C <br/> <br/>Abstract: The study on the sequence specific binding of acridine-4-carboxamides with DNA has been an important topic in the design of new drugs. It has been known that the anticancer properties of acridine-2, acridine-3 and acridine-4-carboxamides are significantly different. So the sequence specific binding of these drugs can be monitored from the intercalative mode of binding by chromophores within DNA. The stacking energies obtained from ab initio, MP2 and DFT methods have been used to understand the sequence preference intercalation by chromophore. Among these drugs, the acridine-4-carboxamide shows maximum stacking with GC base pair in spite of acquiring high potency, but the stacking energy of this drug with AT base pair is not so small. The conformation of carboxamide side chain in acridine-4-carboxamide does not lie in the same plane of chromophore, and also the orientation of side chain in acridine-2 and acridine-3 carboxamides is different from that of acridine-4-carboxamide. <br/> <br/>Page(s): 1483-1494 http://nopr.niscair.res.in/handle/123456789/3852 Title: Naphthalene azomesogens with terminal chloro groups <br/> <br/>Authors: Thaker, B T; Patel, D M; Tandel, P K <br/> <br/>Abstract: A homologous series of azomesogens, with terminal chloro groups have been synthesized. All the homologous synthesized compounds exhibit enantiotropic nematic mesophase. The mesomorphic properties of the present series are compared with other structurally related series to evaluate the effect of terminal chloro group and its position on mesomorphism. <br/> <br/>Page(s): 1020-1024 http://nopr.niscair.res.in/handle/123456789/3849 Title: Synthesis of novel aliphatic thiourea derivatives containing s-triazine moiety as potential antimicrobial agents <br/> <br/>Authors: Desai, Akshay D; Mahajan, Dharmesh H; Chikhalia, Kishor H <br/> <br/>Abstract: A new series of aliphatic thiourea and various aryl urea incorporating 1,3,5-s-triazine moiety is reported. This series has been obtained by the reaction of cyanuric chloride with thiophene-2-ethyl thiourea 1. Thus, the prepared 2-(thiophene-2-ethyl thioureido)-4,6-dichloro-s-triazine 2 has been subsequently treated with morpholine to get 2-(thiophene-2-ethyl thioureido)-4-(morpholino)-6-chloro-s-triazine 3. This is further treated with various aryl ureas to afford title compound 4a-j. The library of ureido linkage containing triazinyl moiety has been tested for in vitro antibacterial and antifungal activity against different microorganisms. The structure of novel synthesized compounds has been established on the basis of elemental analysis, ¹H NMR, IR and mass spectral data. <br/> <br/>Page(s): 1169-1173 http://nopr.niscair.res.in/handle/123456789/3847 Title: Ecofriendly solvent free microwave enhanced alkyl migration in N-alkyl anilines in dry media conditions <br/> <br/>Authors: Selvakumar, S; Easwaramurthy, M; Raju, G J <br/> <br/>Abstract: A rapid, cleaner, cost effective and ecofriendly synthesis of exclusive para alkyl anilines in solvent free conditions using solid supports under microwave irradiation is achieved. <br/> <br/>Page(s): 713-715