http://nopr.niscair.res.in/handle/123456789/2240 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/2267 Title: A simplified Cadogan’s approach to synthesis of new isoxazolyl indazoles <br/> <br/>Authors: Rajanarendar, E; Reddy, A Siva Rami; Shaik, Firoz Pasha <br/> <br/>Abstract: Isoxazolyl Schiff bases have been prepared from the corresponding amines by reaction with 2-nitrobenzaldehydes.These nitro compounds undergo de-oxygenative cyclization to give indazoles via nitrenes on heating with triethyl phosphite in acetonitrile. Isoxazolyl indazoles have also been synthesized in a one-pot reaction. <br/> <br/>Page(s): 1591-1596 http://nopr.niscair.res.in/handle/123456789/2266 Title: Synthesis and β-adrenergic blocking activity of naphthyloxypropylamines <br/> <br/>Authors: Vattipalli, Ramya; Shirodkar, Prabhakar Y; Somani, Rakesh R; Kadam, Vilasrao J <br/> <br/>Abstract: A series of 1-isopropylamino-3-(3'-substituted-2'-naphthyloxy)-2-propanols have been synthesized and their structures have been confirmed by spectral analysis. All the derivatives have shown β-adrenergic blocking effect when tested on perfused frog heart. Compound 4e exhibited 100% blockade of adrenaline response. <br/> <br/>Page(s): 1587-1590 http://nopr.niscair.res.in/handle/123456789/2265 Title: Synthesis and biological evaluation of 2-aminobenzothiazole derivatives <br/> <br/>Authors: Srivastava, S D; Sen, J P <br/> <br/>Abstract: As a part of systematic investigation of synthesis and biologically active compounds of 2-amino benzothiazoles, several new [(2"-substituted aryl)-4"-oxo-1",3"-thiazolidine-3"-iminoacetyl]-2-aminobenzothiazole 5 and [(5"-arylidene-2"-substituted aryl-4"-oxo-1",3"-thiazolidine)-3"-iminoacetyl]-2-aminobenzothiazole 6 from 2-aminobenzothiazole have been synthesized. All the synthesized products are evaluated for their antibacterial activity against Bacillus substilis, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporum and Trichoderma viride. The structures of all the synthesized compounds have been determined by spectral and chemical methods. <br/> <br/>Page(s): 1583-1586 http://nopr.niscair.res.in/handle/123456789/2264 Title: Facile ZrCl₄ promoted four-component coupling one-pot synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction <br/> <br/>Authors: Reddy, Ch Sanjeeva; Raghu, M <br/> <br/>Abstract: ZrCl₄ catalyzed efficient unsymmetric Hantzsch reaction via four-component coupling reaction of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temperature is described as the preparation of polyhydroquinoline derivatives. The process presented here is an operationally simple, economic, environmentally benign and provides excellent yield. Furthermore, the catalyst can be recovered conveniently and reused efficiently. <br/> <br/>Page(s): 1578-1582