http://nopr.niscair.res.in/handle/123456789/1722 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/1752 Title: Ceric(IV) ammonium nitrate catalyzed synthesis of β-enaminones <br/> <br/>Authors: Paira, M; Misra, R; Roy, S C <br/> <br/>Abstract: β-Enaminones have been synthesized in good yield from 1,3-dicarbonyl compounds and activated amines in the presence of ceric ammonium nitrate as catalyst. <br/> <br/>Page(s): 966-969 http://nopr.niscair.res.in/handle/123456789/1751 Title: Beckmann rearrangement of α-oximinoketones <br/> <br/>Authors: Kumar, B N Hitesh; Prakasam, T; Srinivasan, P S; Arabindoo, Bhanumathi; Ramana, D V <br/> <br/>Abstract: The Beckmann rearrangement of α-oximinoketones gives benzoic acids as chief isolable products. Both first order and second order Beckmann rearrangements have been observed. The occurrence of first order Beckmann rearrangement in these oximinocarbonyl compounds is confirmed through the identification of the products obtained. <br/> <br/>Page(s): 963-965 http://nopr.niscair.res.in/handle/123456789/1750 Title: Quantitative structure-activity relationship studies of a new class of selective aldose reductase inhibitors <br/> <br/>Authors: Sharma, R; Sahoo, P K; Chaturvedi, S C <br/> <br/>Abstract: Quantitative structure activity relationship studies on a series of [1,2,4]Triazino[4,3-a] benzimidazole acetic acid derivatives with selective aldose reductase inhibitor activity is made using a combination of various physicochemical descriptors. This is a new class of triazino benzimidazole derivatives having selective activity with minimum toxic effects. Several significant equations with good co-efficient of correlation (≥ 0.854) are obtained; the best model is selected using predictive ability of equations. The model shows positive contribution of logP towards biological activity i.e., high hydrophobic nature of the molecules might be increasing the selective aldose reductase inhibitor activity. <br/> <br/>Page(s): 957-962 http://nopr.niscair.res.in/handle/123456789/1748 Title: Chemical constituents of Dendrobium gratiosissimum and their cytotoxic activities <br/> <br/>Authors: Zhang, Chao-Feng; Wang, Min; Wang, Lei; Iinuma, Munekazu; Zhang, Mian; Xu, Luo-Shan; Wang, Zheng-Tao <br/> <br/>Abstract: Two new bibenzyl derivatives, named dengraols A 1 and B 2, are isolated from stems of Dendrobium gratiosissimum Rchb. (Orchidaceae), together with seven known compounds: 3,5,4′-trihydroxybibenzyl 3, 3,4′-dihydroxy- 5-methoxybibenzyl 4, 3, 4 - dihydroxy-5, 4′ - dimethoxy bibenzyl 5, 3, 4′ - dihydroxy - 4, 5, 3′-trimethoxybibenzyl (moscatilin) 6 and 5, 4′- dihydroxy -3, 3′- dimethoxybibenzyl (gigantol) 7, 5, 3′, 4′-trihydroxy - 3- methoxybibenzyl (tristin) 8 and 5, 3′- dihydroxy- 3-methoxybibenzyl (batatasin III) 9. Among the isolated compounds, dengraols A 1 and B 2, moscatilin 6 and gigantol 7 showed inhibitory activity of proliferation on HL-60 cells with IC₅₀ values at 2.1, 6.4, 0.082 and 10.6 μM, respectively. <br/> <br/>Page(s): 952-956