NISCAIR Online Periodicals Repository Collection: IJC-B Vol.51B(10) [October 2012]

Synthesis and biological screening of 1-N-{4′-[4′′, 4′′′-difluoro diphenyl)-methyl]-piperazine-1′-yl}-4-arylidene-2-penyl-5-oxo-imidazolines

Title: Synthesis and biological screening of 1-N-{4′-[4′′, 4′′′-difluoro diphenyl)-methyl]-piperazine-1′-yl}-4-arylidene-2-penyl-5-oxo-imidazolines

Authors: Savaliya, M D; Dobaria, J G; Bhuva, V V; Purohit, H D; Purohit, D M

Abstract: 1-N[(4′-[4′′,4′′-Difluorodiphenyl)-methyl]-piperazine-1′-yl}-4-arylidene-2-phenyl-5-oxo-imidazolines 3a-j have been synthesized by the condensation of 1-amino-4-[(4′, 4′′–difluorodiphenyl)-methyl]-piperazine with different oxazolones. The products have been assayed for their antimicrobial screening against Gram +ve and Gram –ve bacteria, and fungi. Some of the products show moderate activity compared with known standard drugs viz. ampicillin, chloramphenicol, norfloxacin and greseofulvin at the same concentration 50 µg/mL. The structures of the products have been elucidated by IR, ¹H NMR, mass spectral data and elemental analysis.

Page(s): 1517-1520

A green synthesis and antibacterial activity of 2-aryl-5-(coumarin-3-yl)-thiazolo [3,2-b][1,2,4]triazoles

Title: A green synthesis and antibacterial activity of 2-aryl-5-(coumarin-3-yl)-thiazolo [3,2-b][1,2,4]triazoles

Authors: Jakhar, Komal; Makrandi, J K

Abstract: 3-Aryl-5-(coumarin-3-yl)acylthio-1,2,4-triazoles 1a-h have been prepared by direct condensation of 3-acetylcoumarins and various 3-aryl-5-mercapto-1,2,4-triazoles in the presence of molecular iodine using grinding technique at room temperature. 3-Aryl-5-(coumarin-3-yl)acylthio-1,2,4-triazoles on cyclisation with polyphosphoric acid using microwave irradiations under solvent free conditions give 2-aryl-5-(coumarin-3-yl)-thiazolo[3,2-b][1,2,4]triazoles 2a-h. The present method is quite environmentally benign as it avoids the use of hazardous organic solvents during the reaction as well as at working up stage. Several new compounds have been synthesized and their antibacterial properties have been described.

Page(s): 1511-1516

Synthesis and antimicrobial screening of 4H -2-acetyl-3-amino- furo [3,2-c] benzopyran 4-one, oxime of 4H-2-acetyl-3-amino-furo [3,2-c] benzopyran 4-one, 11H-2-chloromethyl-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide and 11H-2-[methylene morpholine]-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide.

Title: Synthesis and antimicrobial screening of 4H -2-acetyl-3-amino- furo [3,2-c] benzopyran 4-one, oxime of 4H-2-acetyl-3-amino-furo [3,2-c] benzopyran 4-one, 11H-2-chloromethyl-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide and 11H-2-[methylene morpholine]-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide.

Authors: Mulwad, V V; Hegde, A S

Abstract: A mixture of 2H-3-cyano-4-hydroxy benzopyran 2-one 4a-d, anhydrous potassium carbonate and chloroacetone has been refluxed in dry acetone to give 4H-2-acetyl-3-amino furo [3,2-c] benzopyran 4-one 5a-d. A solution of 5a-d, hydroxylamine hydrochloride in ethanol followed by aqueous potassium hydroxide has been heated to get oxime of 4H-2-acetyl-3-amino-furo [3,2-c] benzopyran 4-one 6a-d. 6a-d which is treated with chloroacetyl chloride in acetone and triethyl amine gives 11H-2-chloromethyl-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide 7a-d. 7a-d has been further treated with ethanolic solution of morpholine to give 11H-2-[methylene morpholine]-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide 8a-d. The structures of all these compounds have been established on the basis of the spectral and analytical data. All compounds have been screened for their antifungal and antibacterial activity and have been found to exhibit good activity.

Page(s): 1504-1510

Ferulic acid ester from Colebrookea oppositifolia

Title: Ferulic acid ester from Colebrookea oppositifolia

Authors: Verma, Suresh Kumar; Pareek, Deepika; Singhal, Reenkoo; Chauhan, Ashok Kumar; Parashar, Pradeep; Dobhal, Mahabeer P

Abstract: Chemical investigation of the petroleum ether extract of the leaves of Colebrookea oppositifolia Smith syn. C. ternifolia Roxb. (Lamiaceae) afford five compounds namely n-triacontane, cetyl alcohol, 32-hydroxydotriacontyl ferulate, b-sitosterol and 5,6,7,4′-tetramethoxyflavone. Isolation of 32-hydroxydotriacontyl ferulate is being reported for the first time from this plant. Structures of these compounds have been elucidated on the basis of spectral (IR, NMR, MS) data.

Page(s): 1502-1503