http://nopr.niscair.res.in/handle/123456789/1394 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/1433 Title: Synthetic potentiality of α-chloronitrone in aldehyde synthesis: A new approach <br/> <br/>Authors: Chakraborty, Bhaskar; Chhetri, Manjit Singh <br/> <br/>Abstract: N-Phenyl-N-cyclohexyl-α-chloronitrones have been synthesized and a new method of synthesis of aldehyde has been discovered involving SNi and SN² reactions with benzyl chloride. <br/> <br/>Page(s): 485-487 http://nopr.niscair.res.in/handle/123456789/1432 Title: Yttrium triflate-catalyzed reactions of indoles with electron-deficient olefins <br/> <br/>Authors: Sun, Liangdong; Gao, Changshui; Zhou, Weiyi; Wei, Yuping <br/> <br/>Abstract: The reaction condition for Michael addition of indoles to a series of electron-deficient olefins catalyzed by Y(OTf)₃ has been carefully optimized at ambient temperature and the reaction affords the corresponding Michael adducts in good to excellent yields with high selectivity. Y(OTf)₃ is also found to be able to catalyze the Michael addition of furan. <br/> <br/>Page(s): 481-484 http://nopr.niscair.res.in/handle/123456789/1431 Title: Synthesis and antimicrobial activity of some new pyrazolo[3,4-d]pyrimidines and thiazolo[4,5-d]pyrimidines <br/> <br/>Authors: Akbari, J D; Mehta, K B; Pathak, S J; Joshi, H S <br/> <br/>Abstract: The desired fused ring system 3-isopropyl-4-aryl-1,4,5,7-tetrahydropyrazolo[3,4-d] pyrimidin-6-ones 4a-d have been synthesized by the reaction of 5-isopropyl-2,4-dihydro-3-pyrazolone 1, urea and different aromatic aldehydes, while 7-aryl-6,7-dihydro-3H,4H-thiazolo[4,5-d]pyrimidine-2,5-diones 7a-d have been synthesized by using 2,4-thiazolidine 5 instead of 5-isopropyl-2,4-dihydro-3-pyrazolone 1. The structures of the compounds have been characterized by elemental analysis, IR, ¹H NMR, and mass spectroscopy. The antibacterial activity of the newly synthesized compounds have been tested against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739 and Pseudomonas aeruginosa ATCC 1539; antifungal activity against Candida albicans ATCC 10231 have been tested using the disk diffusion method. Compounds 4b, 4c, 4d, 7c and 7d are found to be active against S. aureus ATCC 6538 (MIC: 185, 78, 156, 72 and 102 μg/mL respectively) and compounds 4d and 7d against C. albicans ATCC 10231 (MIC: 312.5 μg/mL). The minimum inhibitory concentrations of these compounds have been determined using the micro dilution method. <br/> <br/>Page(s): 477-480 http://nopr.niscair.res.in/handle/123456789/1430 Title: Synthesis and characterization of some novel isoxazoles and 1,5-benzothiazepines bearing s-triazine nucleus <br/> <br/>Authors: Solankee, Anjani; Kapadia, Kishor; Solankee, Pankit; Prajapati, Yogesh; Patel, Hiral; Solankee, Sejal <br/> <br/>Abstract: The title compounds 7a-d and 8a-d have been prepared starting from chalcones 6a-d having s-triazine nucleus. These chalcones 6a-d on cyclisation with hydroxylamine hydro- chloride in presence of alkali and 2-aminothiophenol in presence of a few drops of glacial acetic acid give isoxazoles 7a-d and 1,5-benzothiazepines 8a-d respectively. All the products have been characterized by elemental analysis, IR, 1H NMR and LCMS data. <br/> <br/>Page(s): 473-476