http://nopr.niscair.res.in/handle/123456789/12640 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/12674 Title: Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives <br/> <br/>Authors: Mariappan, G; Bhuyan, N R; Kumar, Pradeep; Kumar, Deepak; Murali, K <br/> <br/>Abstract: [1-(N-substituted amino) methyl]-2-ethyl benzimidazole deri­vatives <b style="">1-10</b> have been<b style=""> </b>synthesized by the condensation of 2-ethyl benzimidazole with substituted primary and secondary amines. Their structures have been elucidated by UV-Vis, IR, ¹H NMR and mass spectral data. Among the synthesized derivatives <b style="">1, 2, 8, 9</b> and <b style="">10</b> are found to have an effective anti-inflammatory response whereas compounds <b style="">2, 4, 6, 8</b> and <b style="">10</b> have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles derived from secondary and primary amines. All the experimental data were statistically significant at P&lt;0.05 level. <br/> <br/>Page(s): 1216-1219 http://nopr.niscair.res.in/handle/123456789/12673 Title: Synthesis and antibacterial activity of some novel <i>N</i>-substituted 3-[4-(1-alkyl/acyl/aroyl-1<i>H</i>-benzimidazol-2-yl)phenyl]acrylate derivatives <br/> <br/>Authors: Chaudhari, Raju B; Vaidya, Sanjay D; Karale, B K; Pawar, P Y; Rindhe, Sahebrao S <br/> <br/>Abstract: Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1<i>H</i>-benzimidazol-2-yl)phenyl]acrylate derivatives has been reported. These derivatives are prepared by condensation of <i style="">o</i>-phenyle­nediamine with 4-bromobenzoic acid to give 2-(4-bromophenyl)-1<i>H</i>-benzimidazole which undergoes Heck reaction with alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these compounds with different types of electrophiles afford a series of the corresponding 1N-substituted alkyl/acyl/­aroyl/sulfonyl derivatives. Furthermore, the antibacterial activities of these compounds have been checked against <i style="">Staphylococcus aureus</i> and <i style="">Salmonella typhimurium</i> bacterial strains but the results are found to be disappointing. <br/> <br/>Page(s): 1208-1215 http://nopr.niscair.res.in/handle/123456789/12672 Title: Synthesis and characterization and anti-inflammatory and antibacterial evaluation of 3-arylidene-7-methoxychroman-4-ones <br/> <br/>Authors: Shankar, T; Gandhidasan, R; Venkataraman, S <br/> <br/>Abstract: 3-Arylidene-7-methoxychroman-4-ones <b style="">3a-k</b> have been prepared from 7-methoxy-chroman-4-one <b style="">1</b> and heterocyclic aldehydes <b style="">2</b> and have been evaluated for anti-inflammatory and antibacterial activities. All of them have registered moderate anti-inflammatory and antibacterial activities. <br/> <br/>Page(s): 1202-1207 http://nopr.niscair.res.in/handle/123456789/12671 Title: Synthesis and antibacterial activities of new dibenzothiazepine derivatives <br/> <br/>Authors: Mahale, Ganesh D; Kolekar, Yogesh M; Kumar, Ashok; Singh, Dharmendra; Kodam, Kisan M; Waghmode, Suresh B <br/> <br/>Abstract: A number of substituted dibenzo[<i style="">b,f</i>][1,4]thiazepines analogues carrying heterocyclic and aliphatic moiety attached to C-11 position have been synthesized and evaluated their antibacterial activities against gram positive and gram negative bacteria. Derivatives of imidazole, 2-methyl imidazole and pyrrolidine exhibit significant antibacterial activities. <br/> <br/>Page(s): 1196-1201