http://nopr.niscair.res.in/handle/123456789/12482 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/12520 Title: Synthesis and anticancer activity of some new series of 1, 4-dihydropyridine derivatives <br/> <br/>Authors: Kumar, R Surendra; Idhayadhulla, A; Nasser, A Jamal Abdul; Murali, K <br/> <br/>Abstract: A series of 1,4-dihydropyridine derivatives <b>1a-c</b> have been prepared from 4-substituted aromatic aldehyde, ethyl acetoacetate and ammonium hydroxide following Hantzsch method. The compounds <b>1a-c</b> have been reacted with semicarbazide to give the compounds<b> 2a-c</b>. The compounds <b>1a-c</b> have been reacted with thiosemicarbazide to give the compounds<b> 3a-c</b>. The structures of synthesized compounds are confirmed by IR, ¹H and ¹³C NMR, mass spectrometry and elemental analyses. The newly synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound <b>2a</b> is highly active against HepG2, MCF-7 and <b>3a</b> is highly active against Hela (Cervical) and these have been selected for advanced preclinical development. <br/> <br/>Page(s): 1140-1144 http://nopr.niscair.res.in/handle/123456789/12519 Title: Chemical composition and antimicrobial activity of the essential oil from the rhizome of <i style="">Canna indica</i> Linn <br/> <br/>Authors: Indrayan, A K; Bhojak, N K; Kumar, Nikhil; Shatru, Ajat; Gaur, Abhishek <br/> <br/>Abstract: The essential oil of the rhizome of <i style="">Canna indica</i> Linn. (yellow flower variety) has been isolated by hydrodistillation and analysed by GC and GC/MS. Forty-three compounds representing 95.32% of the oil have been identified. The sesquiterpene hydrocarbons and their derivatives form the major part (52.56%). The major terpene/terpenoid constituents of the essential oil of rhizome are <img src='/image/spc_char/gamma2.gif' border=0>-eudesmol (9.79%), δ-cadinol (6.33%), <img src='/image/spc_char/gamma2.gif' border=0>-selinene (5.23%) and luciferin (5.05%). Surprisingly, certain fatty acids are also found to be present in noticeable amount, palmitic acid (8.53%) being the main. The oil showed good antibacterial activity against <i style="">Staphylococcus aureus</i> but mild activity against <i style="">Bacillus subtilis</i> <br/> <br/>Page(s): 1136-1139 http://nopr.niscair.res.in/handle/123456789/12518 Title: An efficient and simple synthesis of tetraketones catalyzed by Yb(OTf)₃-SiO₂ under solvent free conditions <br/> <br/>Authors: Rao, V Kameshwara; Kumar, Muthyala Manoj; Kumar, Anil <br/> <br/>Abstract: A novel and efficient three-component one-pot condensation method has been described for the synthesis of tetraketones or arylmethylene[<i style="">bis</i>(3-hydroxy-2-cyclohexene-1-ones)] using Yb(OTf)₃-SiO₂ and amine as catalytic system under solvent free conditions. Tetraketones are obtained in high yield (73-88%). The application of an eco-friendly, non-corrosive, and reusable catalytic system makes this method advantageous. <br/> <br/>Page(s): 1128-1135 http://nopr.niscair.res.in/handle/123456789/12517 Title: A simple and efficient bromoazidation of alkenes using PTT and TMSN₃ in ionic liquid <br/> <br/>Authors: Kumar, Anil; Rao, M Sudershan; Mehta, Vibhor <br/> <br/>Abstract: A simple and efficient one-pot method has been described for the bromoazidation of alkenes using phenyltrimethylammonium tribromide (PTT) and TMSN₃ in ionic liquid. The bromoazides have been obtained in good to excellent yield from various alkenes such as styrenes, chalcones, and cycloalkenes at room temperature. <br/> <br/>Page(s): 1123-1127