http://nopr.niscair.res.in/handle/123456789/12091 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/12101 Title: Antibacterial evaluation of some novel 5-imidazolones <br/> <br/>Authors: Solankee, Anjani; Patel, Ghanshyam; Patel, Kirti <br/> <br/>Abstract: The title compounds are prepared by the reaction between different azlactones <b style="">1a-j</b> and thiophene-2-ethylamine <b style="">2</b>. The constitution of all the synthesized compounds has been established by their physical properties, elemental analysis and spectral analysis (IR and ¹H NMR spectra). All the synthesized compounds have been screened for their <i style="">in vitro </i>antibacterial activity by using Gram positive and Gram negative bacteria. <br/> <br/>Page(s): 949-952 http://nopr.niscair.res.in/handle/123456789/12100 Title: Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors <br/> <br/>Authors: Sengupta, Saumitra; Rao, G Venkateshwar; Dubey, P K <br/> <br/>Abstract: A new series of 5-fluoro-3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, <b style="">7a-c</b>, 3-[(4-substituted-phenylaminooxalyl)-amino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid, <b style="">7d-h</b> and 5-(2,6-difluoro-phenoxy)-3-[(substituted-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid, <b style="">7i-p</b> have been synthesized from N-(substituted-phenyl)-oxalamic acid, <b style="">1 </b>and their activities have been evaluated <i style="">in vitro</i>. Compounds <b style="">7b</b>,<b style="">c </b>and <b style="">k</b> show low micromolar inhibitory activity against caspase-3. <br/> <br/>Page(s): 901-905 http://nopr.niscair.res.in/handle/123456789/12099 Title: A mild and efficient four component one-pot synthesis of 2,4,5-triphenyl-(1<i style="">H</i>-1-imidazolyl)isoxazoles catalyzed by ceric ammonium nitrate <br/> <br/>Authors: Rajanarendar, E; Murthy, K Rama; Reddy, M Nagi <br/> <br/>Abstract: Ceric ammonium nitrate (CAN) acts as an efficient catalyst for the synthesis of 2,4,5-triphenyl-1<i style="">H</i>-1-imidazolyl isoxazoles in a four component one-pot condensation of benzil or benzoin, aromatic aldehyde, isoxazole amine and ammonium acetate. This one-pot procedure is very simple, affording excellent yields in shorter reaction time at ambient temperature. Isoxazole amines are employed as one of the synthon in this multi-component condensation for the first time. <br/> <br/>Page(s): 926-930 http://nopr.niscair.res.in/handle/123456789/12098 Title: Synthesis and antibacterial activity of benzamides and sulfonamide derived from 2-amino-5-bromo/nitropyridine against bacterial strains isolated from clinical patients <br/> <br/>Authors: Rai, Diwakar; Singh, Ramendra K <br/> <br/>Abstract: A series of 5-(bromo/nitropyridin-2-yl)benzamide derivatives, <i style="">viz.</i> <i>N</i>-(5-bromopyridin-2-yl)benzamide<b> 4a</b><b style="">,</b> 4-methyl-<i>N</i>-(5-bromopyridin-2-yl)benzamide <b>4b, </b>4-chloro-<i>N</i>-(5-bromopyridin-2-yl)benzamide<b> 4c, </b>4-nitro-<i>N</i>-(5-bromopyridin-2-yl)benzamide<b> 4d</b>, <i>N</i>-(5-nitropyridin-2-yl)benzamide<b> 7a</b><b style="">,</b> 4-methyl-<i>N</i>-(5-nitropyridin-2-yl)benzamide<b> 7b</b><b style="">,</b> 4-chloro-<i>N</i>-(5-nitropyridin-2-yl)benzamide <b>7c</b><b style="">,</b> 4-nitro-<i>N</i>-(5-nitropyridin-2-yl)benzamide<b> 7c </b>and a sulfo­namide derivative, <i>N</i>-benzoyl-<i>N</i>-(5-bromopyridin-2-yl)trifluoro­methane sulfonamide<b> 5 </b>have been synthesized&nbsp; as novel&nbsp; anti­bacterial agents. All compounds have shown promising activity (MIC 0.22–1.49 <img src='/image/spc_char/micro.gif' border=0>M) against Gram-positive and Gram-negative bacterial strains using microdilution broth susceptibility test method. The sulfonamide <b style="">5</b> showed much better results than other compounds and its MIC values predicted it to be a lead compound as an antibacterial agent. <br/> <br/>Page(s): 931-936