http://nopr.niscair.res.in/handle/123456789/11176 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/11186 Title: Synthesis and antimicrobial activity of 1-aminomethyl-3-[4′-(4″-nitrobenzyloxy)-benzohydrazono]isatins <br/> <br/>Authors: Rastogi, Nisheeth; Harrison, Darwin Anil; Agarwal, Akriti <br/> <br/>Abstract: A new series of 1-aminomethyl-3-[4′-(4″-nitrobenzyloxy)-benzo­hydrazono]isatins (Mannich bases) have been synthesized and screened for their antimicrobial potential against human pathogenic bacteria and fungi. The structures of the compounds have been established by means of elemental analysis and spectral data (IR and ¹H NMR). <br/> <br/>Page(s): 330-333 http://nopr.niscair.res.in/handle/123456789/11185 Title: Spectral and single crystal X-ray diffraction studies of (<i style="">E</i>)-4-chloro-<i style="">N</i><b>^′</b>(2-hydroxy­benzylidene)benzohydrazide <br/> <br/>Authors: Padmaja, A; Begum, Aliya; Ragavaiah, P; Devi, Ch Sarala <br/> <br/>Abstract: (<i style="">E</i>)-4-Chloro-<i style="">N</i>^′(2-hydroxybenzylidene)benzohydrazide is synthesized and characterized by elemental analysis, IR, ¹H NMR, ¹³C NMR, DEPT and mass spectral studies. The structure and types of hydrogen bonding present in crystalline form of title compound are envisaged from single crystal X-ray diffraction studies. The topological analysis of hydrogen bonds indicates both inter and intramolecular hydrogen bonding. The presence of water molecule in crystal structure indicates mono hydrated form of the title compound. <br/> <br/>Page(s): 326-329 http://nopr.niscair.res.in/handle/123456789/11184 Title: Synthesis of thiazolyltriazole substituted azetidinones as antimicrobial agents <br/> <br/>Authors: Baviskar, B A; Shiradkar, M R; Khadabadi, S S; Deore, S L; Bothara, G <br/> <br/>Abstract: The reaction of ethyl 2-amino-4-methylthiazole-5-carboxylate <b style="">1</b> with acetic anhydride followed by reaction with hydrazine hydrate yields the ethyl 2-acetamido-4-methylthiazole-5-carboxylate <b style="">2</b> and <i style="">N</i>-[5-(hydrazinecarbonyl)-4-methylthiazol-2-yl]acetamide <b style="">3</b>, respectively. The compound <b style="">3</b> on further reaction with alcoholic potassium hydroxide-carbon disulphide followed by cyclization with hydrazine hydrate gives <i style="">N</i>-[5-(4-amino-5-mercapto-4<i style="">H</i>-1,2,4-triazol-3-yl)-4-methylthiazol-2-yl]acetamide<b style=""> 5</b>. The compound <b style="">5</b> is then condensed with different aromatic aldehydes to offer Schiff bases <b style="">6a-h</b>. The Schiff bases on cyclization with chloroacetyl chloride in presence of triethylamine as catalyst furnish the azetidin-2-one <b style="">7a-h</b>. The compounds are synthesized in good yield and the chemical structures of the compounds are elucidated from their IR, ¹H NMR, and elemental analysis. All the synthesized compounds have been screened for their antimicrobial activity. <br/> <br/>Page(s): 321-325 http://nopr.niscair.res.in/handle/123456789/11183 Title: Studies on synthesis of various N-substituted derivatives with different heterocycles and their herbicidal activity <br/> <br/>Authors: Mashelkar, U C; Tungare, Shefali S; Bhagat, Sachin <br/> <br/>Abstract: Coumarin 4-methyl acetates are oxidized to coumarin-4-methyl glyoxalate using SeO₂. Unlike the oxidative decaboxylation observed in the case of coumarin-4-acetic acid, here the oxidation is very selective for active methylene group, without affecting the COOH group protected with ester function. The product thus formed is analogous to the phenyl glyoxalic acid methyl ester i.e. coumarin 4-methyl glyoxalate and can be a useful moiety for the various synthetic manipulations of heterocycles substituted at 4-position of the coumarin showing promising herbicidal activity. Different heterocycles substituted at 4-position of the coumarin moiety have been synthesized. The herbicidal activity of these compounds has been evaluated. Zea Mays and Green Gram have been used for pre-emergence and post-emergence screening of the herbicidal activity. <br/> <br/>Page(s): 315-320