Indian Journal of Experimental Biology

http: // www.niscair.res.in

 

VOLUME 48

NUMBER 3

MARCH 2010

CODEN: IJEB (A6) 48 (3) 181-328 (2010)

ISSN: 0019-5189 (Print); 0975-1009 (Online)

 

CONTENTS

 

Special Issue on New Drug Discovery from Natural Products

 

Foreword

185

 

 

Preface

187

 

 

Review Articles

 

Impact of natural products in modern drug development

191

Sukh Dev

 

 

 

Natural products drug discovery research in India: Status and appraisal

199

Kamlesh K Bhutani & Vikrantsinh M Gohil

 

 

 

Drug development from natural products: Exploiting synergistic effects

208

Gudrun Ulrich-Merzenich, D Panek, H Zeitler, H Vetter & H Wagner

 

 

 

Natural products drug discovery: Accelerating the clinical candidate development using reverse pharmacology approaches

220

Bhushan Patwardhan & Ashok D B Vaidya

 

 

 

Natural toxins and their therapeutic potential

228

V K Kapoor

 

 

 

Arjunolic acid: A novel phytomedicine with multifunctional therapeutic applications

238

Thiagarajan Hemalatha, Sivasami Pulavendran, Chidambaram Balachandran, Bhakthavatsalam Murali Manohar & Rengarajulu Puvanakrishnan

 

 

 

Papers

 

Antiproliferative cardenolides from Pentopetia androsaemifolia Decne. from the Madagascar rain forest

248

Eba Adou, James S Miller, Fidisoa Ratovoson, Chris Birkinshaw, Rabodo Andriantsiferana, Vincent E Rasamison & David G I Kingston

 

 

 

Screening of natural products for therapeutic activity against solid tumors

258

Bassem S El-Menshawi, Walid Fayad, Khaled Mahmoud, Salwa M El-Hallouty,
May El-Manawaty, Maria H臠g Olofsson & Stig Linder

 

 

 

Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity

265

Vikrantsinh M Gohil, Satyam K Agrawal, Ajit K Saxena, Divita Garg, C Gopimohan & Kamlesh K Bhutani

 

 

 

Anti-ulcer and antioxidant activity of GutGardTM

269

Moumita Mukherjee, Natarajan Bhaskaran, R Srinath, H N Shivaprasad, J Joshua Allan, D Shekhar & Amit Agarwal

 

β-Amyrin from Ardisia elliptica Thunb. is more potent than aspirin in inhibiting collagen- induced platelet aggregation

275

Jianhong Ching, Tung-Kian-Chua, Lee-Cheng Chin, Aik-Jiang Lau, Yun-Keng Pang, Johannes Murti Jaya, Chay-Hoon Tan & Hwee-Ling Koh

 

 

 

Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin

280

Hesham A El-Beshbishy, Ahmed M Mohamadin, Ayman A Nagy &
Ashraf B Abdel-Naim

 

 

 

Elucidation of possible mechanism of analgesic action of Valeriana wallichii DC. chemotype (patchouli alcohol) in experimental models

289

Sangeeta Pilkhwal Sah, Chandra S Mathela & Kanwaljit Chopra

 

 

 

Antihyperglycemic activity of compounds isolated from Indian medicinal plants

294

Akanksha , Arvind K Srivastava & Rakesh Maurya

 

 

 

Comparative effect of Ocimum sanctum, Commiphora mukul, folic acid and ramipril on lipid peroxidation in experimentally-induced hyperlipidemia

299

Naresh Khanna, Deepika Arora, Sumita Halder, Ashish K Mehta, Gobind R Garg,
Suman B Sharma & Prabha Mahajan

 

 

 

Comparative evaluation of Bacopa monniera and Panax quniquefolium in experimental anxiety and depressive models in mice

306

Manavi Chatterjee, Pinki Verma & Gautam Palit

 

 

 

Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.

314

Amandeep Kaur, Ranvir Singh, Chinmoy Sankar Dey, Shyam Sunder Sharma,
Kamlesh K Bhutani & Inder Pal Singh

 

 

 

Assessment of protective role of polyherbal preparation, Livinia, against anti-tubercular drug induced liver dysfunction

318

Kavita Gulati, Arunabha Ray & V K Vijayan

 

 

 

On-line HPLC-DPPH method for antioxidant activity of Picrorhiza kurroa Royle ex Benth. and characterization of kutkoside by Ultra-Performance LC-electrospray ionization quadrupole time-of-flight mass spectrometry

323

Pamita Bhandari, Neeraj Kumar, Bikram Singh & Paramvir S Ahuja

 

 

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Announcement

 

International Biennial Conference

on

New Developments in Drug Discovery from Natural Products and Traditional Medicines

(2024 November, 2010)

 

The conference will be held at National Institute of Pharmaceutical Education and Research (NIPER), Phase X, Sector - 67, S.A.S. Nagar 160062, India. The topics covered in the conference will focus on frontiers of natural product and traditional medicines based drug discovery programs; participation of the pharmaceutical industries in natural drug development programme; and possible collaboration of scientists/researchers globally for drug discovery from natural products. The registration for participation will be opened from March 1, 2010. For further details, please contact Professor K. K. Bhutani, Organizing Secretary-cum-convener, Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, SAS Nagar 160062, India. E-mail: ddnptm@niper.ac.in; kkbhutani@niper.ac.in. Telefax: 0172-2232208; 0172-2292036 (Websites: www.niper-ddnptm.com; www.naturalproducts-niper.com; www.niper.gov.in).