Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 49B


February 2010







Enantioselective synthesis of diarylmethanols using microbial transformation


Diaryl ketones are reduced enantioselectively to the (S)-diarylmethanols using fungus Rhizopus arrhizus. The physicochemical parameters like microbe selection, reaction time, temperature, etc. for the bioreduction reactions are optimized by taking p-chloro benzophenone as a model substrate.









P R Salokhe, G S Rashinkar & R S Salunkhe*


Department of Chemistry, Shivaji University, Kolhapur 416 004, India









Modern Friedel-Crafts Chemistry. Part 30­1. Facile synthesis of isomeric tri- and tetramethyl­tetra­hydrophenanthrenes via rearranged cycli­alkyla­tion of suitably methylated 1-(1- and 2-naphthyl)-3-pentanols


Simplified Friedel-Crafts cyclialkylation approaches towards the syntheses of isomeric 1,1,2- and 3,4,4-trimethyl-1,2,3,4-tetrahydrophenanthrenes and isomeric 1,1,2,2- and 3,3,4,4-tetramethyl-1,2,3,4-tetrahydrophenanthrenes are reported.



α - or β-Naphthyl (R=H, CH3)               from α-isomer         fromβ-isomer




Ali Ali Khalaf *, Hassan A Albar & Khalid O El-Fouty


Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt















Synthesis and antibacterial activities of some novel isoxazolidine derivatives derived from
N-phenyl-α-chloro nitrone in water

1,3 dipolar cycloaddition reaction of N-phenyl-α-chloro nitrone with different dipolarophiles have been studied in water for the synthesis of novel isoxazolidines. Significant rate acceleration and high yield of these reactions are observed in water with remarkable changes in stereo and regioselectivity compared to organic solvents. The structures of all compounds have been established on the basis of spectral and analytical data. All compounds have been screened for their antibacterial activity and found to be active.




Bhaskar Chakraborty*, Manjit Singh Chhetri, Saurav Kafley & Amalesh Samanta


Organic Chemistry Laboratory, Sikkim Govt. College, Gangtok 737 102, India









Synthesis and photochemical H-abstractions of some 2-thienyl/furyl-3-allyloxybischromones


Synthesis and photolysis of some bischromones built around trans-2-butene and 2-butyne have been described.





Rupesh Kumar & Mohamad Yusuf*


Department of Chemistry, Punjabi University, Patiala 147 002, India








Structural optimization of new class of selective carbonic anhydrase inhibitors: QSAR approach


QSAR studies on a new class of sulfonamide derivatives with selective carbonic anhydrase inhibitory activity have been performed using a combination of various physicochemical descriptors. The best equation selected emphasized on high hydrophobic groups, presence of electron donating groups, size and shape of molecule might be influencing the selective carbonic anhydrase inhibitory activity.


Parent Nucleus


Blessy Pothen, Vineet Singh, Surendra Kumar & Meena Tiwari*


Computer Aided Drug Design Lab, Department of Pharmacy, Shri Govindram Seksaria Institute of Technology and Science, 23, Park Road, Indore 452 003, India.














Facile ketone sensitized photochemical ring opening of isoxazolidines to β-enaminocarbonyl compounds

A methodology for the inter- and intramolecular ketone sensitized photochemical cleavage of ixoxazolidine moiety to furnish b-enaminocarbonyl compounds is reported. A series of experiments on isoxazolidines under different sets of irradiation conditions have been conducted to delineate the mechanistic details, in particular, the photosensitization by carbonyl moiety.







Rajinder Singh, Gurmit Singh & Mohan Paul S Ishar*


Bio-organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143 005, India

















Syntheses of aromatic aldehyde imine derivatives of 2-thiobenzyl-1, 3, 4-thiadiazole and evaluation of their anticonvulsant activity


Benzyl and chlorobenzyl substituted 1, 3, 4-thiadiazole imine derivatives have been prepared and found to show good anticonvulsant activity. Chlorobenzyl substituted compounds show potent activity against phenytoin as standard reference. Neurotoxicity has been screened through the Rota rod and ethanol potentiation test. The compounds did not show any neurotoxicity.







Bahar Ahmed* & Md. Yusuf


Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110 062, India















Chemoselective reaction of malononitrile with imine-ones and antifungal potential of products








Anjali Sidhu*, J R Sharma & Mangat Rai


Department of Chemistry, bDepartment of Plant Pathology, Punjab Agricultural University, Ludhiana 141 004, India








Photo-Fries rearrangement of naphthalene-1,5-diyl bis(4-chlorobutanoate): Exclusive and regioselective mono-rearrangement


Photo-Fries rearrangement of naphthalene-1,5-diyl bis(4-chlorobutanoate) provides only the mono-rearranged product with the other ester remaining intact.







K Balamurugan, M Bhama & V Sridar*


Industrial Chemistry Lab, Central Leather Research Institute, Adyar, Chennai 600 020, India









Potassium triiodide catalyzed Friedlander synthesis of 1,8-naphthyridines in aqueous media


Potassium triiodide catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds contain­ing a-methylene group 2 in aqueous media to afford 1,8-naph­thy­­ri­dines 3 in high yields.




K Mogilaiah*, K Shiva Kumar & N Vasudeva Reddy


Department of Chemistry, Kakatiya University, Warangal 506 009, India















New constituents from Psoralea corylifolia


Two new metabolites, psoralester 1 and psorachromene 2 together with five known compounds have been isolated from the seeds of Psoralea corylifolia and their structures have been elucidated on the basis of their detailed NMR and mass spectral data.



                                                        1                                                          2



Amit Tewari & R S Bhakuni*


Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226 015, India









A new route for the synthesis of (R)-glycer­aldehyde acetonide: a key chiral building block


A new route for the synthesis of (R)-glyceraldehyde acetonide via asymmetric dihydroxylation of allyl 4-methoxy benzoate using the (DHQ)2PHAL, K2OsO4·2H2O catalyst system is described. This route involves the asymmetric dihydroxylation of allyl 4-methoxy benzoate, acetonide protection of vicinyl dihydroxyl groups followed by cleavage of p-methoxy benzoate ester and subsequent oxidation to give the (R)-glyceraldehyde acetonide.






K Chandra Babu, G Ramadasu, L Gangaiah,  G Madhusudhan* & K Mukkanti


aInogent Laboratories Private Limited, A GVK BIO Company, 28A, IDA, Nacharam, Hyderabad 500 076, India









Synthesis of benzofuran analogs of fenamates as non steroidal antiinflammatory agents


Series of benzofuran analogs of fenamates are easily synthesized by conventional heating method. All the compounds were screened for antiinflammatory activity.




Balasaheb Y Mane*, Y S Agasimundin & B Shivakumar


SVPM’s College of Pharmacy, Malegaon BkII, Baramati 413 115, India















Ecofriendly synthesis of thieno[2,3-b]pyridines  derivativies


2-Aminothiophenes are readily transformed to thienopyridines using suitable solvent system.



M Kidwai*, Priya & R Poddar


Green Research Laboratory, Department of Chemistry, University of Delhi, North Campus, New Delhi 110 007, India.






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