Indian Journal of Chemistry

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Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 49B

NUMBER 4

April 2010

CONTENTS

Papers

 

 

 

461

A novel one pot room temperature ionic liquid mediated synthesis of 1,5-benzodiazepine ribo­furanosides

 

A novel one pot ecofriendly synthesis of 7-substituted/7,8-disubstituted-2,2,4-trisubstituted-1-(2′,3′,5′-tri-O-benzoyl-β-d-ribofuranosyl)-2,3-dihydro-1,5-benzodiazepines has been accomplished stepwise, i.e. reacting o-phenylenediamine and a ketone in the first step followed by addition of β-d-ribofuranose-1-bromo-2,3,5-tribenzoate. The yields (72-90%) of the targeted compounds are excellent.

 

 

 

 

Ashok K Yadav*, Manoj Kumar, Tripti Yadav & Renuka Jain

 

Department of Chemistry, University of Rajasthan, Jaipur 302 055, India

 

 

 

 

 

 

469

Efficient microwave activation of hydrotalcite clays in Michael addition under solvent-free conditions

 

Microwave irradiation has been successfully utilized for the activation of unmodified hydrotalcite clays, in the Michael addition reaction under solventless conditions. A plausible mechanism for hydrotalcite catalysis is presented.

 

 

Sakthivel Vijaikumar & Kasi Pitchumani*

 

School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India

 

 

 

 

 

 

 

 

 

 

 

 

475

One- pot synthesis of antifungal active 9-substi­tuted-3-aryl-5H,13aH-quinolino [3,2-f][1,2,4]tria­zolo [4,3-b][1,2,4]triazepines

 

The title compounds, 9-substituted-3-aryl-5H,13aH-quino­lino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines 8, are synthe­sized from 5-aryl-3,4-diamino-1,2,4-triazoles 5 and 2-chloro-3-formylquinolines 7 using catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium using microwave heating as well as solvent using oil-bath heating at 80оC affords novel 9-substituted-3-aryl-5H,13aH-quino­lino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines. The products are obtained in the good to moderate yields and are in a state of high purity.

 

 

 

Monika Gupta*, Satya Paul & Rajive Gupta

 

Department of Chemistry, University of Jammu, Jammu 180 006, India

 

 

 

 

 

 

 

482

Three component one pot synthesis of β-amino ketones mediated by (bromodimethyl)sulfonium bromide

 

 

 

 

M Shailaja, A Manjula & B Vittal Rao*

 

Organic Division - II, Indian Institute of Chemical Technology, Hyderabad 500 607, India

 

 

 

 

 

 

 

Notes

 

 

 

 

 

 

487

A facile synthesis of N-substituted maleimides

 

A simple and efficient method for the synthesis of N-substituted maleimides from the corresponding maleamic acids under the phase transfer catalysis has been described.

 

 

 

Sunita R Deshpande*, Shailaja P Maybhate, Anjali P Likhite & Preeti M Chaudhary

 

Organic Chemistry Division, National Chemical Laboratory, Pune 411 008, India

 

 

 

 

 

 

 

 

 

 

 

 

 

489

Purification of lignin peroxidase from Hexagona tenuis MTCC-1119 and its kinetic properties in aqueous medium containing miscible organic solvents

 

Hexagona tenuis MTCC-1119 secretes lignin peroxidase of molecular wt.48 kDa which retains 50% of its activity in 10% of the water miscible organic solvents acetone, dioxane, diethyl ether, acetonitrile and dimethyl formamide in aqueous medium.

 

 

 

Meera Yadav*, Sunil Kumar Singh, Kamlesh Singh Yadav & Kapil Deo Singh Yadav

 

Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India

 

 

 

 

 

 

 

495

Synthesis  of heneicos-6(Z)-en-11-one, dec-5(Z)-en-1-yl acetate, dec-5(Z)- en-1-yl 3-methylbutano­ate (insect sex pheromones)

 

Synthesis  of heneicos-6(Z)-en-11-one 1, dec-5(Z)-en-1-yl acetate 2, dec-5(Z)-en-1-yl 3-methylbutano­ate 3 has been accomplished by utilizing sodium acetoxyborohydride generated in situ from sodium borohydride and acetic acid as the key step for selective hydroboration-iodination/oxidation.

 

 

 

Rani Jindal, Aarti Devi, Goverdhan L Kad & Jasvinder Singh*

 

Department of Chemistry & Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh  160 014, India

 

 

 

 

 

 

 

500

Efficient synthesis of 9-aryl-6-(2-fluorophenyl)-1,2,4-triazolo[4,3-a][1,8]naphthyridines using chlora­mine-T under microwave irradiation

 

A simple and highly efficient procedure has been described for the synthesis of 9-aryl-6-(2-fluoro-phenyl)-1,2,4- triazolo[4,3-a][1,8]naphthyridines 8 by oxidation of the corresponding aryl aldehyde3-(2-fluorophenyl)-1,8-naphthyridin-2-ylhydrazones 7 with chloramines-T in ethanol under microwave irradiation.

 

 

 

K Mogilaiah*, K Dhanaja, N Srivani & A Vinay Chandra

 

Department of Chemistry, Kakatiya University,Warangal 506 009, India

 

 

 

 

 

 

 

 

 

 

 

 

505

Synthesis and study of chlorosubstituted 4-aroyl and 4-alkoyl-pyrazolines, pyrazoles and their effect on some flowering plants

 

Some 4-aroyl and 4-alkoyl-pyrazoline 5a,b from 3-aroyl and 3-alkoylchromanone 4a,b respectively and 4-aroyl and 4-alkoylpyrazole 7a,b from 3-aroyl and 3-alkoylchromone 6a,b respecttively have been synthesized. Synthesized compounds have been characterized by analytical and spectral studies.

 

 

 

 

Jaishree D Mahale, S C Manoja, N G Belsare* & P R Rajput

 

Department of Chemistry, Vidyabharati Mahavidyalaya, Amravati 444 604, India

 

 

 

 

 

 

 

512

Facile synthesis of acyclic analogues of carbo­cyclic nucleoside as potential anti-HIV pro-drug

 

Microwave induced montmorillonite K10 clay catalyzed Michael addition of sulphur nucleophile, (4-oxo-butyl)-dithiocarbamic acid 1 to 4-arylidene-5(4H)-oxazolones 2a-j followed by ring transformation of the resultant Michael adducts 3a-j which then undergo intramolecular nucleophilic attack on 2 with the simultaneous cleavage of the oxazolone ring to yield 4a-j in solvent-free conditions. The control Aldol condensation of compound 4a-j with HCHO gives compound 5a-j, which upon selective reduction with NaBH4 gives the title compound 6a-j.

 

 

Ibadur R Siddiqui*, Pravin K Singh, Vishal Srivastava & J Singh

 

Laboratory of Green Technology-Synthesis Division, Department of Chemistry, University of Allahabad,
Allahabad 211 002, India

 

 

 

 

 

 

 

 

 

 

 

 

521

Synthesis of some new N-[4-acetyl-4,5- dihydro-5-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl) -5-methyl-1,3,4-thiadiazol-2-yl]acetamide derivatives

 

The synthesis of some new N-[4-acetyl-4,5-dihydro-5-(1-aryl- 5-methyl-1H-1,2,3-triazol-4-yl)-5-methyl-1,3,4-thiadiazol-2-yl] acetamide derivatives was reported in paper.

 

 

 

 

Hui-Cheng Wang, Rong-Shan Li, Hong-Ru Dong & Heng-Shan Dong*

 

State Key Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry,
College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, P.R. China

 

 

 

 

 

 

 

526

Development and assessment of green synthesis of hydrazides

An expeditious, solvent-free one pot method for the preparation of hydrazides from corresponding acids directly under microwave irradiation was developed and assessed using green chemistry matrices.

 

 

 

 

Ajoy Saha, Rajesh Kumar*, Rajendra Kumar & C Devakumar

 

Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi 110 012, India

 

 

 

 

 

 

 

532

Synthesis of new isoxazolyl coumarins by eco-friendly dipyridine cobalt chloride catalyzed Pechmann reaction at ambient temperature

 

Dipyridine cobalt chloride is used as an alternative conven­tional Lewis acid catalyst in the Pechmann condensa­tion of isoxazolyl phenols with β-ketoesters leading to the formation of isoxazolyl coumarins.

 

 

 

 

E Rajanarendar*, Firoz Pasha Shaik & M Nagi Reddy

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

536

Book Review

 

 

 

 

 

Authors for correspondence are indicated by (*)